Measurement of Corticosterone is used as an adjunct to 11-deoxycorticosterone and 11-deoxycortisol measurement in the diagnosis of CYP11B1 and CYP11B2 deficiencies, rare glucocorticoid responsive Hyperaldosteronism and isolated loss of function of 18 hydroxylase and 18 methyloxidase activity of CYP11B2. It also helps to evaluate Congenital Adrenal Hyperplasia in newborns where elevation of 17 hydroxyprogesterone is only moderate.