This assay is useful in evaluating patients with Celiac disease including those with compatible symptoms, atypical symptoms and individuals at increased risk such as those positive for HLA DA2/DQ8 . It is also used as a screeing test for Dermatitis herpetiformis. This assay also monitors adherence to gluten free diet. Test sensitivity increases from 91.5% for tTG IgA antibody alone to 98.5 % when both IgA and IgG antibodies are tested together.