This assay is useful in evaluating patients with Celiac disease including those with compatible symptoms, atypical symptoms and individuals at increased risk like positivity for HLA DQ2 / DQ8. It is also used as a screening test for Dermatitis herpetiformis. The test monitors adherence to gluten free diet.Test sensitivity increases from 91.5% for tTG IgA antibody alone to 98.5% when both IgA and IgG results are considered.